| SYCAMORE TRUST U.K. | £403k | FY2025 | |
| SYD UK | £121k | FY2025 | |
| SYDENHAM ARTS LTD | £41k | FY2025 | going concern |
| SYDENHAM COMMUNITY ASSOCIATION | £100k | FY2026 | |
| SYDENHAM COMMUNITY CLUB (LEAMINGTON SPA) | £112k | FY2024 | reserves below policy |
| SYDENHAM GARDEN | £659k | FY2025 | |
| SYDENHAM NEIGHBOURHOOD INITIATIVES LIMITED | £288k | FY2025 | reserves below policy |
| SYDENHAM ROAD UNDER FIVES | £157k | FY2026 | |
| THE SYDER FOUNDATION | £378k | FY2025 | |
| SYDERSTONE HAPPY FACES PLAYGROUP | £81k | FY2025 | |
| SYDERSTONE VILLAGE HALL (KNOWN LOCALLY AS AMY ROBSART VILLAGE HALL) | £30k | FY2025 | |
| SYDNEY AND PHYLLIS GOLDBERG MEMORIAL CHARITABLE TRUST | £134k | FY2024 | |
| THE SYDNEY AND SHEILA MCGHEE CHARITABLE TRUST | £38k | FY2025 | |
| THE SYDNEY BLACK CHARITABLE TRUST LIMITED | £70k | FY2025 | |
| THE SYDNEY BRENNER CHARITABLE TRUST | £277k | FY2024 | |
| SYDNEY DEAN WHITEHEAD'S CHARITABLE TRUST | £64k | FY2026 | |
| THE SYDNEY DRISCOLL NEURO-SCIENCE FOUNDATION | £26k | FY2025 | |
| SYDNEY E FRANKLIN DECEASED'S NEW SECOND CHARITY | £34k | FY2025 | |
| SYDNEY HOWARD LOVELL MEMORIAL ALMSHOUSES | £233k | FY2025 | |
| SYED HAMID CHARITABLE TRUST | £100k | FY2025 | |
| SYEDA FATIMIA TRUST | £28k | FY2025 | |
| SYEDA ZAHRA TRUST INTERNATIONAL | £67k | FY2025 | |
| SYEDA ZAINAB TRUST | £58k | FY2025 | |
| Syke Community Base | £93k | FY2025 | |
| SYKEHOUSE SHOW SOCIETY | £30k | FY2025 | |
| SYKEHOUSE VILLAGE HALL AND RECREATION GROUND | £41k | FY2025 | |
| SYLFAEN CYMUNEDOL CYF | £136k | FY2025 | |
| SYLVA FOUNDATION | £864k | FY2025 | trustee payments |
| SYLVANUS CHARITABLE TRUST | £114k | FY2025 | |
| SYLVANUS LYSONS CHARITY | £354k | FY2025 | |
| THE SYLVIA AND COLIN SHEPHERD CHARITABLE TRUST | £737k | FY2025 | |
| THE SYLVIA BEAUFOY CENTRE | £310k | FY2026 | |
| SYLVIA LANKA FOUNDATION | £27k | FY2025 | |
| THE SYLVIA SHORT EDUCATIONAL CHARITY | £27k | FY2026 | |
| SYLVIA WADDILOVE FOUNDATION UK | £45k | FY2024 | |
| THE SYLVIA WEBBER TRUST | £122k | FY2025 | reserves below policy |
| SYLVIA WRIGHT TRUST | £438k | FY2025 | |
| THE SYMBOL TRUST | £693k | FY2024 | reserves below policy |
| SYMMETRICAL | £30k | FY2025 | |
| SYMONDS GREEN COMMUNITY ASSOCIATION | £77k | FY2025 | |
| THE SYMPATHETIC TRUST | £877k | FY2025 | |
| SYMPOSIUM MAMMOGRAPHICUM | £310k | FY2025 | |
| SYNAGOGUE MAHARIM DUSHINSKY LIMITED | £347k | FY2025 | |
| SYNCHRONICITY EARTH | £12.0m | FY2025 | |
| THE SYNCONA FOUNDATION | £4.0m | FY2025 | |
| SYNCOPE TRUST AND REFLEX ANOXIC SEIZURES | £107k | FY2024 | |
| THE SYNERGY CHRISTIAN TRUST | £49k | FY2025 | |
| SYNERGY DANCE OUTREACH | £124k | FY2025 | |
| SYNERGY SPHERE | £134k | FY2025 | |
| SYNERGY THEATRE PROJECT | £484k | FY2025 | |
| SYNOD OF GERMAN-SPEAKING LUTHERAN, REFORMED AND UNITED CONGREGATIONS IN GREAT BRITAIN | £511k | FY2024 | |
| SYNTHONIA SCOUT GROUP | £31k | FY2024 | going concern |
| SYRACUSE UNIVERSITY (USA) LONDON PROGRAM | £9.2m | FY2025 | |
| SYRESHAM VILLAGE HALL | £31k | FY2025 | |
| SYRIAN ORTHODOX CHURCH | £452k | FY2025 | |
| SYRIAN REFUGEE RELIEF FUND | £268k | FY2025 | |
| THE SYRO MALANKARA CATHOLIC CHURCH UK | £174k | FY2025 | |
| SYSTON AND DISTRICT VOLUNTEER CENTRE | £132k | FY2025 | |
| SYWELL AND OVERSTONE PRE-SCHOOL | £146k | FY2025 | |
| THE SZILVAY FOUNDATION | £336k | FY2025 | |